细胞和分子生物学

抽象的

A Comprehensive Study between Autoimmune Diseases Related to Age and Autoimmunity

Alfreda Azzariti

Age is an important threat for autoimmunity, and numerous autoimmune conditions preferentially do in the alternate half of majority when vulnerable capability has declined and thymic T cell generation has desisted. Numerous forbearance checkpoints have to fail for an autoimmune complaint to develop, and several of those are susceptible to the vulnerable aging process. Homeostatic T cell proliferation which is substantially responsible for T cell loss during majority can lead to the selection of T cells with increased affinity to tone- or neoantigen s and enhanced growth and survival parcels. These cells can acquire a memory- suchlike phenotype, in particular under lymphopenic conditions. Accumulation of end-discerned effector T cells, either specific fortone-antigen or for idle contagions, have a low activation threshold due to the expression of signaling and non-supervisory motes and induce anseditiousterrain with their capability to be cytotoxic and to produce in ordinate quantities of cytokines and there by converting or amplifying autoimmune responses.