国际标准期刊号: 2155-9872

分析与生物分析技术杂志

开放获取

我们集团组织了 3000 多个全球系列会议 每年在美国、欧洲和美国举办的活动亚洲得到 1000 多个科学协会的支持 并出版了 700+ 开放获取期刊包含超过50000名知名人士、知名科学家担任编委会成员。

开放获取期刊获得更多读者和引用
700 种期刊 15,000,000 名读者 每份期刊 获得 25,000 多名读者

索引于
  • CAS 来源索引 (CASSI)
  • 哥白尼索引
  • 谷歌学术
  • 夏尔巴·罗密欧
  • 学术期刊数据库
  • 打开 J 门
  • Genamics 期刊搜索
  • 期刊目录
  • 研究圣经
  • 中国知网(CNKI)
  • 乌尔里希的期刊目录
  • 电子期刊图书馆
  • 参考搜索
  • 研究期刊索引目录 (DRJI)
  • 哈姆达大学
  • 亚利桑那州EBSCO
  • OCLC-世界猫
  • 学者指导
  • SWB 在线目录
  • 虚拟生物学图书馆 (vifabio)
  • 普布隆斯
  • 欧洲酒吧
  • ICMJE
分享此页面

抽象的

A Concise Study of Organic Volatile Impurities in Ten Different Marketed Formulations by [GC/HS-FID/MS] Gas Chromatography Technique

Gnana Raja M, Geetha G and Sankaranarayanan A

Organic solvents such as Methanol, Isopropyl alcohol and Dichloromethane frequently used in sustained release or controlled release dosage form in pharmaceutical industry for coating. The good choice of solvent for coating of modified release dosage form is Methanol, Isopropyl alcohol and Dichloromethane. A selective Gas Chromatographic GC/HS-FID method has been developed and validated as per ICH guidelines for residual solvent quantification and confirmed the mass number by GC/HS-MS method. The separation was carried out on DB 624 column (30 m, 0.53 mm, [ID] 0.25 mm coating thickness), using Perkin Elmer/Clarus 500 GC/MS, with nitrogen as carrier gas in the split mode by head space injection method. The method described is simple, sensitive, rugged, reliable and reproducible for the quantization of Isopropyl alcohol, methanol and Dichloromethane at residual level in marketed modified release dosage form. In this paper completely demonstrated the method of quantification of residual solvents by GC/HS/FID and confirming by GC/HS/MS of the residual solvents present in 10 different marketed products availed in southern part of India. The enteric coated product has been selected and experiment was performed.