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Acinic Cell Carcinoma of the Breast (ACC): Morphological and Molecular Features of Rare Breast Cancer

Liu Min, Zhang Hongkai

Acinic Cell Carcinoma of the breast (ACC) is a very rare subtype of breast cancer, being of bland cellular morphology, but having a triple-negative phenotype. Usually, it was thought to be indolent, but a few cases have been reported highly aggressive. The molecular studies showed similar features in diagnosing to the Triple-Negative Breast Cancer (TNBC), which usually had the aggressive clinical course. This mini review comprehensively summarizes the recent literature on the molecular features of this rare breast cancer. We try to explain why some ACC have not the indolent course as we thought previously.