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Saalim Nazki, Nisar A. Chowdari, Fazl Q. Parray, Rauf A Wani and Lubna Samad
Adenocarcinoma arising from a chronic anorectal fistula is rare of which there are no more than 200 cases in literature. There has been some debate as to whether the fistula is the source of the tumor, or whether the fistula is the presenting feature of the tumor itself. Fistula and associated anal glands are indeed the source of this unusual tumor. A patient of chronic perianal fistula-in-ano was identified to have developed perianal adenocarcinoma from chronic fistula in ano on biopsy postoperatively. Fistula-associated perianal mucinous adenocarcinoma is an uncommon malignant transformation of chronic fistula-in-ano.