我们集团组织了 3000 多个全球系列会议 每年在美国、欧洲和美国举办的活动亚洲得到 1000 多个科学协会的支持 并出版了 700+ 开放获取期刊包含超过50000名知名人士、知名科学家担任编委会成员。

开放获取期刊获得更多读者和引用
700 种期刊 15,000,000 名读者 每份期刊 获得 25,000 多名读者

索引于
  • 哥白尼索引
  • 谷歌学术
  • 打开 J 门
  • Genamics 期刊搜索
  • 宇宙IF
  • 参考搜索
  • 哈姆达大学
  • 亚利桑那州EBSCO
  • OCLC-世界猫
  • 普布隆斯
  • 日内瓦医学教育与研究基金会
  • 欧洲酒吧
  • ICMJE
分享此页面

抽象的

Aging and Dry Eye: Age-Related Changes in the Function of the Ocular Sensory Apparatus Likely Underlie Dry Eye Symptoms

Anat Galor, Elizabeth R. Felix, Constantine D. Sarantopoulos, Eden R. Martin5 and Roy C. Levitt*

Dry eye is a multifactorial disease impacting the ocular surface that results in symptoms of discomfort, visual disturbance, and tear film instability associated with potential damage to the ocular sensory apparatus. Dry eye is diagnosed in approximately 3.2 million U.S. women and 1.7 million U.S. men older than 50 years of age. While the natural history of dry eye remains to be determined, dry eye rates increase with age, reaching the highest among women 75-79 years of age and men 80-84 years of age. Many patients with dry eye describe features of neuropathic pain, including spontaneous pain, hyperalgesia and allodynia, suggesting dysfunction of the ocular sensory apparatus, which likely impacts the lacrimal functional unit altering basal and reflex tear secretion. Co- morbid conditions such as depression and post-traumatic stress disorder commonly associated with other chronic pain conditions provide further evidence that dry eye may be associated with central processing abnormalities. In fact, recent data show dry eye represents a chronic overlapping pain condition that is significantly impacted by environment and shared genetic factors. In the following sections we review how aging may impact the anatomical structures associated with dry eye. Among other factors, sensitization of the ocular sensory apparatus occurs which occurs with aging is likely influenced by multiple environmental and genetic factors common to other chronic pain conditions and an important driver of ocular pain and dry eye symptoms with aging.

免责声明: 此摘要通过人工智能工具翻译,尚未经过审核或验证。