成瘾研究与治疗杂志

抽象的

An Agenda for Naloxone Distribution Research and Practice: Meeting Report of the Surviving Opioid Overdose with Naloxone (SOON) International Working Group

Aaron M Orkin, Katherine Bingham, Michelle Klaiman, Pamela Leece, Jason E Buick Fiona Kouyoumdjian, Laurie J Morrison and Howard Hu

Opioid-related mortality is a serious and growing issue in North America. Naloxone distribution and basic life support training for people at risk of overdose is a promising opportunity to improve access to potentially lifesaving bystander interventions and essential healthcare. We convened a unique international working group of experts in public health, resuscitation science, and health research methodology, along with clinical, community, policy, industry stakeholders and members of the lay public to explore and address key challenges and opportunities for rigorous research on this intervention.

The findings from the Surviving Opioid Overdose with Naloxone (SOON) International Working Group explored potential research opportunities and identified barriers in four priority areas: research methods, resuscitation guidelines, naloxone delivery device development, and knowledge translation. This novel collaborative effort:

• Identified key steps and challenges for developing an appropriate, feasible and rigorous pragmatic trial of naloxone distribution in various clinical settings;

• Identified emerging naloxone delivery devices and technologies, and described how these devices may alter standards of care for overdose prevention research and practice

• Engaged resuscitation experts in the development of bystander resuscitation protocols for opioid-associated resuscitative emergencies; and,

• Identified strategies to overcome knowledge translation barriers for patients and providers, as well as characteristics for effective educational tools and program implementation.

The SOON collaboration aims to advance the investigation, implementation, and practice of overdose education and naloxone distribution. Through diverse collaborations, we can use best science to improve practice for individuals at risk of opioid overdose.