生物化学与细胞生物学杂志

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Anorexia Lowers GFAP+ in the Valuation and Choice Circuit of Decision Making: A Two-Layered Diffusion Model Rat Hippocampus Cell Density

Irtysh Joe

In neurobiology, a circuit of alternative evaluation and selection is regarded as an accurate model. The significant literary contributions on this subject are included. This study uses a two-layered network of computational cells to model the evaluation and selection of a decisional process during a Two-Alternative Forced-Choice (TAFC) problem,where information gathering and processing advance via nonlinear diffusion dynamics. Two linked diffusive modules (2LDM), which reflect the neuronal populations engaged in the valuation-and-decision circuit of decision making, are thus used to describe the evolution of the response-to-stimulus map. Diffusion models are ideally suited to explain the gradual accumulation of data over time. Under the ex-Wald distribution hypothesis, this enables the estimation of the response times (RTs) in valuation and choice. The two layers' activities are integrated using a nonlinear transfer function. The 2LDM is consistent with the reinforcement learning strategy thanks to the input-output map built on the infomax principle. The activity-dependent modulatory component of the effective connection between the neuronal populations may be explained by 2LDM, according to the results of simulated likelihood time series. The 2LDM's compliance with the neurobiology of DM is further supported by the rhythmic variations of the estimate gain functions in the delta-beta bands.

A common eating disorder among young women is anorexia nervosa. Although the neurobiology of the condition is unknown, recent magnetic resonance imaging studies on anorexic patients revealed a volume reduction of the hippocampus. A mouse model called dehydration-induced anorexia (DIA) mimics the main characteristics of this illness, including dramatic weight loss brought on by voluntarily reducing food intake. It is unknown if anorexia affects the density of the astrocytes, which mediate the energy supply to the brain. Therefore, the purpose of this study was to calculate the GFAP+ cell density in the major hippocampal regions using the DIA model. A common eating disorder among young women is anorexia nervosa. Our findings revealed that, with the exception of CA1, the density of GFAP+ cells were dramatically decreased (20%) throughout the whole hippocampus. It's interesting to note that DIA dramatically decreased the ratio of GFAP+ cells to nuclei in the CA2 (by around 23%) and dentate gyrus (by about 48%). The decrease in GFAP+ cell density correlated with a decrease in GFAP protein expression. The expression of nestin and vimentin, two intermediate filaments, was also elevated in anorexia. As a result, anorexia more than doubled the amount of reactive astrocytes in CA2 and the dentate gyrus. We find that anorexia decreases the number of GFAP+ cells in the hippocampus region while increasing vimentin and nestin expression.