临床与实验神经免疫学杂志

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Anti-Hu Antibody- and Anti-Zic4 Antibody-Positive Paraneoplastic Neurological Syndrome Presenting with Cerebellar Degeneration and Cranial Neuropathy: A Case Report

Ioannis Kourtesis, Maria Orianou, Yannis Asteris, Gerasimos Georgatos, Maria Maltezou

We present an illustrative case of a 62-year-old woman who developed progressive worsening of neurological symptoms with the simultaneous involvement of both peripheral and central nervous system. Our patient presented high titers of Anti-Hu and anti-Zic4 antibodies in her serum. We review the literature and found that multiple cranial palsies and concurrent cerebellar degeneration are uncommon in anti-Hu paraneoplastic syndromes. The patient was treated with intravenous immunoglobulin and methylprednisolone without significant improvement of symptoms.