兽医医学与健康杂志

抽象的

Arsenic Induced Alternation in Animals by its Toxicity

Hina Ayub

This study assessed the developmental and behavioral effects of chronic arsenic exposure in animals. Therefore,the current research is to study the effects of arsenic trioxide on nephrotoxicity, hepatoxicity, and nephrotoxicity.Attempts to monitor the effect of arsenic are based on extensive literary research, with special emphasis on thelatest works. Arsenic is a carcinogen to both humans and animals. Arsenicals have been associated with skin, lung,and bladder cancers of the skin, lung, and bladder. Arsenic (As) is classified as a metalloid and exhibits both metallicand nonmetallic properties. It is found in ore and crust rocks with average density. It exhibits a complex chemistry,occurring in four different valences (-III, O, III and V), and in many different chemical forms and it has these beingused for a wide variety of industrial and agricultural purposes. Arsenic oxide is the most important arsenic compoundused in industry and is used to synthesize other inorganic and biological weapons. Arsenic trioxide is now used totreat acute promonocytic leukemia. Absorption occurs primarily through ingestion in the small intestine, althoughless absorption occurs through skin contact and respiration. Acute arsenic poisoning was initially associated withnausea, vomiting, abdominal pain, and severe diarrhea, and peripheral neuropathy was reported. Chronic arsenicpoisoning can cause multisystem disease. Affects signaling pathways by being able to activate proteins such asERK2, p38, and JNK as shown in mammals. A comparison between the phosphorylation sites of these proteins isperformed to determine whether they are observed in water and in mammals