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The aim of this present study report on the biosynthesis and the main optical properties of titanium dioxide (TiO2) nanoparticles (NPs) by a completely green chemistry process using orange skin natural extract as an effective chelating agent. TiO2 metal oxide NPs shows special properties like hydrophobic nature, non-wet ability and high energy band gap. TiO2 have been the focus of many promising applications due to their low-cost availability and biocompatible such as solar cell, photo catalysis, charge spreading devices, chemical sensors, microelectronics, and electrochemistry. In addition to the X-ray diffraction investigations, the raman, attenuated total reflectance (ATR;) and fourier transform IR (FTIR) and infrared as well as the scanning electron microscopy (HR-SEM) while (TEM), and the photoluminescence (PL) emission spectra confirmed the phase tetragonal of the TiO2 nanoparticles. This green synthesis method involving TiO2 NPs explores the advantages of inexpensive and non-toxic precursors.