临床与实验病理学杂志

抽象的

Blastoid Mantle Cell Variant of Richter’s Transformation

John G Prichard, Wayne W Chen, Mrugesh C Shah, Dayana E Tobar and Edmund H Wong

An unusual occurrence of blastoid variant of mantle cell lymphoma arising in a patient with untreated chronic lymphocytic leukemia/small lymphocytic lymphoma is described. A localized site of intense uptake on positron emission tomography suggested Richter's transformation. Biopsy of the suspect area showed the blastoid variant of mantle cell lymphoma. Immunohistochemistry and fluorescence in situ hybridization confirmed the identity of both tumors. Molecular studies established that the mantle cell lymphoma and chronic lymphocytic leukemia/small lymphocytic lymphoma were clonally related.