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Bone Metastases in Metastatic Renal Cell Carcinoma: Now We Know That Cabozantinib Targets Bone Microenvironment

Giuseppe Procopio

The multiple tyrosine kinases inhibitor cabozantinib has shown improvements in progression-free survival (PFS), overall survival (OS) and objective response rate (ORR) in comparison to everolimus in patients with metastatic renal cell carcinoma (mRCC) within the METEOR trial, a phase III clinical trial , randomized, open-label trial [1,2], resulting in its approval in mRCC patients previously treated with antiangiogenic agents.