细胞因子生物学杂志

抽象的

Cell Signaling from Molecular Recognition to Cellular Activation

Lin Chao

Cell signaling plays a crucial role in various physiological and pathological processes, enabling cells to communicate and coordinate their activities. This complex and highly regulated process involves a series of molecular events that ultimately lead to cellular activation or response. Understanding the mechanisms of cell signaling is essential for unraveling the intricate network of intercellular communication and its implications in development, homeostasis, and disease. This review provides an overview of cell signaling and activation, highlighting key components and processes involved. It starts by introducing the concept of cell signaling and the different types of signaling molecules, including hormones, growth factors, neurotransmitters, and cytokines. The discussion then delves into the intricate signaling pathways that cells utilize, such as receptor-mediated signaling, intracellular signal transduction, and gene expression regulation. The major signaling pathways covered include receptor tyrosine kinase (RTK) signaling, G-protein coupled receptor (GPCR) signaling, and nuclear receptor signaling. Each pathway is described in terms of its components, activation mechanisms, and downstream signaling events. Furthermore, the review explores the diverse cellular responses triggered by signaling, including changes in gene expression, metabolism, cell proliferation, differentiation, and apoptosis.