世界药理学与毒理学杂志

抽象的

Clinical Neuropharmacology of Cocaine Reinforcement: An Analysis of Human Laboratory Self-Administration Trials

Atsu Aiba

Cocaine use is an unrelenting public fitness concern. To inform intervention and prevention efforts, it is imperative to increase an appreciation of the medical neuropharmacology of the reinforcing results of cocaine. The cause of this overview is to consider and synthesize human laboratory research that checks pharmacological manipulations of cocaine self-administration. Forty-one peer-reviewed, human cocaine self-administration researches in which contributors obtained a pre-treatment drug had been assessed. The pharmacological motion and remedy routine for all capsules reviewed have been considered. Drugs that enlarge extracellular dopamine have a tendency to have the most constant consequences on cocaine self-administration. The capacity of no dopaminergic tablets to influence cocaine reinforcement may be associated to their downstream outcomes on dopamine, even though it is hard to draw conclusions due to the fact pharmacologically selective compounds are no longer extensively reachable for human testing. The potential of acute versus continual drug therapy to differentially have an effect on human cocaine selfadministration used to be no longer decided due to the fact buprenorphine used to be the solely pre-treatment drug that used to be assessed beneath each acute and continual dosing regimens. Future lookup at once evaluating acute and continual drug remedy and/or evaluating tablets with one of kind mechanisms of action is wanted to make extra conclusive determinations about the scientific neuropharmacology of cocaine reinforcement.