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Ito S *
As an exercise training protocol in comprehensive cardiac rehabilitation, time-efficient high-intensity interval training (HIIT) has been investigated other than guideline based moderate-intensity continuous training. The scientific background of this protocol is that higher intensity exercise works to yield more improvement in aerobic and metabolic function by giving more stimuli to cardiopulmonary system and skeletal muscle. Among many combination of work interval, (active) rest, and frequency, most popular and evidence-based HIIT is 4 × 4 min. This protocol is the first one that has been investigated by multi center randomized controlled trials (RCT). In this mini-review, we discussed the current status and potential of HIIT for cardiac patients by commenting on the results of recently published multi center RCT and review articles.