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Determination of Tinidazole and Ciprofloxacin Hydrochloride in Single Formulation Tablet using Differential Pulse Polarography
Salvi V S, Sathe P A and Rege P V
A simple and precise method for the determination of Tinidazole and Ciprofloxacin hydrochloride from its single formulation tablet has been developed using differential pulse polarography. Tinidazole and ciprofloxacin produces a cathodic wave at -0.38 V and -1.30 V respectively versus S.C.E in a solution of pH = 6.5 (Britton Robison buffer). The dynamic range for Tinidazole, is 0.50 to 279.31μgcm -3 and for Ciprofloxacin, it is 24.39 to 245.28 μgcm -3 . The method has been validated and applied successfully for the determination of the two drugs from their respective formulation.