国际标准期刊号: 2573-4555

传统医学和临床自然疗法

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索引于
  • CAS 来源索引 (CASSI)
  • 谷歌学术
  • 夏尔巴·罗密欧
  • 打开 J 门
  • Genamics 期刊搜索
  • 参考搜索
  • 研究期刊索引目录 (DRJI)
  • 哈姆达大学
  • 亚利桑那州EBSCO
  • 普布隆斯
  • 日内瓦医学教育与研究基金会
  • 欧洲酒吧
  • ICMJE
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抽象的

Determining the In Vitro Effects of Aqueous Elephant Dung and Fadogia ancylantha Leaf Extracts on Isolated Rat Pregnant Uterus Horns

Mawoza T, Magwali T and Nhachi C

Background: In Zimbabwe, elephant dung and Fadogia ancylantha are widely used in the third trimester of pregnancy. They are believed to facilitate childbirth because they open the birth canal during delivery. However, the effects of these medicines in pregnancy have not been investigated. This study aimed to determine the effects of elephant dung and F. ancylantha leaf extracts on isolated pregnant and non-pregnant uterine horns.

Materials and Methods: Elephant dung and Fadogia ancylantha leaves were air-dried, macerated in water, filtered, evaporated and freeze dried. Uterine horns from 72 non-pregnant and 72 pregnant female Sprague-Dawley rats were used. The ‘test’ strips were separately exposed to elephant dung (20-640 mg/ml) or F. ancylantha (25-800 mg/ml) while the 'controls' received distilled water only. Effects of oxytocin on tissues exposed to these extracts were measured.

Results: Elephant dung aqueous extract contracted the uterus in a dose-dependent manner whilst Fadogia ancylantha relaxed uterine tissue in a dose-dependent manner. The effects of both the Elephant dung and Fadogia ancylantha extracts were higher in pregnant uteri versus non-pregnant uteri. Oxytocin potentiated elephant dunginduced contraction, but only slightly shifted baseline upwards in tissues exposed to Fadogia ancylantha.

Conclusion: Elephant dung possessed oxytoxic effects and contracted uteri in a dose-dependent manner. Fadogia ancylantha relaxed the uterus in a dose-dependent manner, suggesting that it might slow down labour progression since uterine contraction will not be occurring at a sufficient enough pace to facilitate labour and delivery. Pregnant women and health care workers need education to understand the possible effects of using these traditional medicines in pregnancy.