分子药剂学与有机过程研究杂志

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Dielectric Spectroscopy in Ibuprofen-Dioxane Mixture

Dr,Manoj K. Saini

In recent years, the dielectric study of amorphous pharmaceuticals has made a considerable effort towards correlating the molecular mobility with their physical and chemical stability. The molecular mobility of amorphous materials is affected by temperature, additives (such as water) and specific interactions (such as Hydrogen bond). Therefore,

to understand the physicochemical instability of amorphous materials, nature of their molecular mobility needs to comprehend. In this order, the Dielectric and Calorimetric measurements were performed on a mixture of ibuprofen and 1,4-dioxane. The αD process is found to be Debye-like (i.e., αHN = 0 and βHN= 1) in nature and α process kinetically freezes at Tg-onset (DSC) implies that α- process indeed corresponds to the glass transition event. Both processes are found to

be non-Arrhenius in nature. In addition, two secondary relaxation processes (designated as βJG and β) are observed and are comparable with the literature. The activation energy of β process indicates that its originating from the fluctuations of the side group larger than -OH group. Also, the calculated fragility index demonstrates that ibuprofen is a fragile glass former.