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抽象的
Differences in Acetic Acid Ototoxicity in Guinea Pigs are Dependent on Maturity
Takafumi Yamano, Hitomi Higuchi, Tetsuko Ueno, Takashi Nakagawa, Tetsuo Morizono
Objectives: The objective was to study if the difference exist in drug ototoxicity between less mature and mature guinea pigs.
Methods: The matured animal group had a body weight of 400 g and the less mature animal group had a body weight of 200 g. After compound action potential of the eight cranial nerves was measured, the middle ear cavity was filled with acetic acid.
Results: The less mature animal group was more sensitive to the acetic acid treatment than the more mature animal group.
Conclusion: We suggest that a difference in ototoxicity of certain otic drop treatments may exist between pediatric and adult patients.