诊断病理学：开放获取

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Effect of RBD Mutation (Y453F) in Spike Glycoprotein of SARS-CoV-2 on Neutralizing Antibody Affinity

Takuma Hayashi, Nobuo Yaegashi, Ikuo Konishi

Background: Infection with Receptor-Binding Domain (RBD) mutant (Y453F) of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) from farmed minks is known to widely spread among humans.

Methods: We investigated the characteristics of SARS-CoV-2 RBD Y453F mutant using three-dimensional structural analysis. We investigated the effect of the RBD Y453F mutant of SARS-CoV-2 on neutralizing antibodies in serum derived from Coronavirus Disease 2019 (COVID-19) positive patients.

Results: Our studies suggest that virus variants with RBD Y453F mutation partially escaped detection by four neutralizing monoclonal antibodies and neutralizing antibodies in serum.

Conclusion: Consequently, raising concern that infection of SARS-CoV-2 mutants that cause serious symptoms in humans may spread globally.