生物技术与生物材料

抽象的

Efficacy of the surface electrodeposition treatment of the biodegradable AZ31 alloy on their in vitro bacterial response

Miguel Angel Pacha Olivenza

The role of metals and metal alloys in implant design focuses mainly. However, it cannot be expected that rigid metallic devices can adapt to the physiological evolution of carrier, especially in the case of children, nor that long term safety can be guaranteed, as in the case of any foreign material within the human body.

In this scenario, biodegradable metals, mainly magnesium and their alloys have been introduced  to suit resorption needs. However, both metals suffer from attack of chloride containing environment, such as human body fluids, but both are elements present in human body, ensuring its non-toxicity for a moderate release. The controlled corrosion rate can result in progressively decreasing mechanical support as implant is replaced by new tissue until the fracture heals. This advantage makes unnecessary any secondary surgery. On the other hand, metal implants are also susceptible to bacterial infection. The local defense system is highly affected by the surgical trauma after implantation, and it is highly susceptible time for bacterial infection.

Hydroxyapatite (HA), that is basically pure calcium phosphate, has favorable osteo-conductive and bioactive properties making it a preferred biomaterial for both biomedical applications. The purpose of this work is to evaluate the applicability of HA coating on biodegradable implant metal, AZ31, using electrodeposition treatment. After conditioning, the morphological and chemical changes of the surfaces are observed in SEM, AFM, Tofsims and hydrophobicity analyses, in addition the adhesion and viability of a strain of Staphylococcus aureus.