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EV71, A Virus with Complicated Pathogenesis in the CNS

Min Feng and Qihan Li

Fatal cases of hand, foot, and mouth disease (HFMD) caused by enterovirus 71 (EV71) infection are characterized by inflammatory damage to the central nervous system (CNS) with slight degeneration of nerve cells. Here, we review several studies that identify potential host factors and possible mechanisms of neuropathogenesis of EV71 infection.