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Expression Alteration of Disrupted in Schizophrenia 1 (DISC1) Gene, a Potential Peripheral Marker for Schizophrenia and Paranoid Personality Disorder

Arvin Haghighatfard

Introduction: Schizophrenia (SCZ) is a major psychiatric disorder with unclear etiology or biological diagnosis. Paranoid Personality Disorder (PPD) is a type A personality disorder characterized by paranoia and generalized mistrust. Disrupted in schizophrenia 1 (DISC1) is a gene located on human chromosome 1 that is involved in neurodevelopment of brain. Variations and translocations in this gene were found associated with schizophrenia and other psychiatric disorders. Present study aimed to evaluate the expression alteration of DISC1 gene in peripheral blood of SCZ and PPD patients and its correlation with clinical features.