我们集团组织了 3000 多个全球系列会议 每年在美国、欧洲和美国举办的活动亚洲得到 1000 多个科学协会的支持 并出版了 700+ 开放获取期刊包含超过50000名知名人士、知名科学家担任编委会成员。

开放获取期刊获得更多读者和引用
700 种期刊 15,000,000 名读者 每份期刊 获得 25,000 多名读者

抽象的

Identification and Treatment of Juvenile Acute Myeloid Leukaemia Stem Cell Splicing Dysregulation

Joseph Campbell

Acute myeloid leukaemia in children (pAML) is characterised by frequent relapses and a dearth of somatic DNA alterations. Splicing dysregulation has not been thoroughly researched in pAML, despite seminal findings showing that splicing factor mutations and mis-splicing fuel therapy-resistant leukaemia stem cell (LSC) production in adults. Here, we discuss transcriptome-wide analyses of FACS-purified hematopoietic stem and progenitor cells followed by differential splicing analyses, dual-fluorescence lentiviral splicing reporter assays, single-cell proteogenomics analyses, and the potential of the selective splicing modulator Rebecsinib in pAML.