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Impact of Haplotype Matching on the Results of Adult Single-Cord Blood Transplantation

Junya Kanda

It remains unclear whether the HLA haplotype of unconnected cord blood (UCB) should be matched to that of the case in single UCB transplantation. Therefore, using data from a Japanese registry, we anatomized the effect of haplotype matching on issues. Cases with hematologic conditions aged 16 times or aged who had experienced their first transplant were included (N = 1347). The goods of haplotype matching and high- frequence HLA haplotype on issues were anatomized. Median patient age was 55 times. The accretive frequentness of neutrophil engraftment among groups with 0, 1, and 2 HLA haplotype matches were 79, 82, and 88, independently( P = .008). In a multivariate analysis, the group with 0 haplotype matches was hardly associated with worse neutrophil engraftment (P = .087) and significantly associated with platelet engraftment (P = .044) compared with the group with 1 haplotype match. Twohaplotype matches were associated with a advanced threat of relapse. In the group with 1 haplotype match, the top 3 participated haplotypes were HLA haplotype matching might be considered to ameliorate engraftment. Two- haplotype matches should be avoided if the relapse threat is high. The haplotype itself may have an effect on the threat of acute graft- versus- host complaint and relapse.