临床神经心理学：开放获取

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Impaired Response Inhibition in Psychosis

Benjamin Pessoa

Inhibitory Control or what is commonly known as Response Inhibition, as a neuropsychological construct is multifaceted and has been studied by a considerably large body of scientific literature. Various aspects of inhibitory control can be linked to different neurobiological, psychiatric, or behavioural implications both in the normal and pathological functioning of the brain. The psychotic spectrum consists of a group of conditions wherein research has revealed profound implications on inhibitory control. On one hand, there are various methodologies that can be successfully employed to study the various aspects of inhibitory control. On the other hand, researchers over the ages have used some classical paradigms to reveal the brain activities underlying this process. The paradigms, methods, and approaches differ from each other and have yielded results that are sometimes consistent with each other, and sometimes seem to contradict the findings in the existing literature. The differences in findings also take an attempt towards explaining the pathological brain on an anatomical, physiological as well as molecular level. The article tried to explore the existing body of literature and come up with a conceptual understanding of how the executive function of inhibitory control gets impaired in the brains of individuals suffering from disorders belonging to the psychotic spectrum and how it can be used as a parameter to separate the diagnosis of different psychotic disorders.