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Roman Pachulski
t has indeed been a long and winding road from cryptogenic stroke to occult AF (AF) with many intervening detours. AF associated with mitral valve disease was identified in 1930 by Harvey as increasing the risk of stroke by 17-fold. In 1991 Wolfe identified a 5-fold increase in stroke risk for AF without mitral valvular disease. In the following year’s warfarin was shown effective in stroke reduction in such patients.