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In Vitro Test and Molecular Docking of Alkaloid Compound in Marine Sponge Cinachyrella anomala against T47D Cell Cycle
Awik Puji Dyah Nurhayati, Rarastoeti Pratiwi, Subagus Wahyuono, Istriyati, Hari Purnomo and Syamsudin Abdillah
The compound 1,4,9-triazatricyclo[7,3,1,0]trideca-3,5(13),10-trien-8-ol (SA2014) was isolated from the marine sponge Cinachyrella anomala. In vitro assay for SA2014 compound was found to be able to induce cell-cycle arrest at the sub-G1 and G2/M phases of T47D cancerous cell. A combined dosage between of SA2014 compound and of doxorubicin was able to induce cell-cycle arrest at sub-G1 and G2/M phases. Molecular docking approach showed that SA2014 compound inhibited cdk2 enzyme. The strength of interaction between SA2014 and cdk2 (docking score = -65,43) was more stable than the interaction between doxorubicin and cdk2 (-36,59).