世界药理学与毒理学杂志

抽象的

Kidney Safety Assessment: Current Drug Development Techniques

Carmela N Keichel

The kidney’s position as a main route of metabolism and clearance of xenobiotics and its potential to listen the glomerular filtrate make it especially prone to drug-induced toxicity. Improving kidney protection is a lively place of lookup and there is a want in early levels of drug improvement for techniques and mannequin structures to reliably discover nephrotoxic compounds and sufficiently represent mechanisms to aid drug pipeline selection making. In later tiers of drug improvement the fee of touchy translational biomarkers to display kidney toxicity throughout species in nonclinical and scientific settings is gaining realization. Various equipment and techniques for kidney security evaluation have emerged over the previous decade; however, there is presently no clear consensus on great practices for their use throughout exclusive phases of drug development. Here, we furnish standpoint on the scope of this hassle in drug development, and an overview of growth in the discipline of kidney security which includes numerous informative case examples of kidney toxicity de-risking eventualities encountered in the pharmaceutical industry. The outcomes of a survey of pharmaceutical agencies performed thru the Innovation and Quality Drug Safety consortium presents extra perception into current experiences with compound attrition and distinctive de-risking methods throughout the industry.