临床与实验神经免疫学杂志

抽象的

Microbial Inflammation and Infection as a Cause of the Onset of Neurodegenerative Diseases

Shimon Shatzmiller, Galina M Zats, Inbal Lapidot, Rami Krieger and Ludmila Buzhansky

For three decades the Amyloid hypothesis was leading in popularity compared to the oxidative stress ideas. It guided researchers in the neurodegenerative diseases area. This idea contributed a lot to the progress of the respective quest for remedy, the amyloids, amylin, insulin and other antimicrobial agents were held responsible for neuron death by their aggregates, fibrils, and plaques. However, it seems today that the culprit is not there. On the other hand, more and more evidence is accumulating to favor an idea that was almost abandoned, the microbial inflammation and infection as the onset and significant cause of neuro-degeneration and death.