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Oral LD50 of total saponins and tannins isolated from Dialium guineense stem bark

Osahon Abu

The safety of bioactive compounds isolated from plant extracts has become a global concern. The aim of this study was to determine the oral LD50 of total saponins and tannins isolated from Dialium guineense stem bark using Sprague Dawley rats. Male Sprague Dawley rats (n=13) weighing 150-180 g (mean weight=165 ± 15 g) were used for this study. The aqueous, ethanol and methanol extracts of the plant stem bark were obtained using cold maceration method. The lorke method was used to determine oral LD50 of isolated total saponins and tannins of D. guineense. Signs of toxicity and possible death of rats were also monitored for twenty-four (24) h.