临床与实验病理学杂志

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Papillary Thyroid Carcinoma with Prominent Hobnail Features Diagnosed Preoperatively by Fine Needle Aspiration and Demonstrating Constitutive Activation of mTOR Signaling Pathway: A Case Report

Jing Liu, Robert E Brown, Sheldon Rubenfeld and Ron J Karni

Papillary Thyroid Carcinoma (PTC) with prominent hobnail features is a recently recognized aggressive variant of PTC. The cytologic features and molecular characterization have not been fully investigated. We present a patient with a preoperative fine needle aspiration diagnosis of PTC with hobnail features that demonstrated constitutive activation of mTOR pathway with evidence of mTORC2 activation on immunohistochemical staining. These findings may be of value for clinical management, targeted therapy, and prognostication.