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Perineural Invasion of Skin Cancers in the Head and Neck: An Uncommon Phenomenon Revisited

Santhosh Gaddikeri, Amit Bhrany and Yoshimi Anzai

Objective: The purpose of this article is to describe the epidemiology, imaging findings, pathogenesis, and clinical impact of perineural invasion of skin cancers in the head and neck.

Conclusion: Perineural invasion in head and neck skin cancer can be microscopic disease discovered on pathology or gross perineural spread that can be predicted on imaging often accompanied with clinical symptoms. Physicians and radiologists should have high index of suspicion when evaluating with patient with skin cancer that is in close proximity to a cranial nerve. The advancement of imaging techniques has improved pre-operative detection of perineural invasion of skin cancer.