分子药剂学与有机过程研究杂志

抽象的

Preliminary Report on Management of HIV/AIDS-Associated Opportunistic Skin Infections with PhytodermaTM, a Natural Myco-Based Cream

Yongabi KA, AdoteyG, Chia PN and Tiagueu YT

Despite the introduction of Highly Active Antiretroviral Therapy (HAART), opportunistic skin diseases continue to be prevalent and persistent in human immunodeficiency virus-infected individuals. Patients in this study were already receiving antiretroviral therapy for more than 2 years presented clinically with skin malaise previously treated unsuccessfully with conventional antifungal and chemotherapeutic agents. An exit pool system where patients consented to be involved in the study was applied. One hundred (100) out of five hundred and thirty (530) HIV/AIDS patients screened, representing 18.7%, were found with cutaneous infectious fungal infections. Of the 100 HIV/AIDS infected patients with cutaneous infectious fungal infections; Tinea pedis and Tinea unguium had prevalence rate of 60%, Tinea capitis 25%, Tinea corporis 15% respectively. Twenty (20) of the patients in the study had dark/ash color skin depigmentations with swollen hard knobs identified as Kaposi sarcoma Continuous culture of scrapings from the skin, head scalp, finger and toe nails from HIV/AIDS infected patients on malt extract, sabaraud dextrose agars in triplicates as well as KOH microscopy revealed the presence of Trichophyton rubrum, Trichophyton Mentagraphyte, Candida albicans and Microsporium spp. Bulk Methanol and water extracts of Ganoderma lucidum sporophore and whole mushroom fruit of Termitomyces titanicus in a 100% concentration inhibited mycelia growth of all the tests fungi in vitro as compared to growth of mycelium on methanol and water control plates with ketoconazole 200 mg/ ml (undiluted). Crude methanol and water extracts of Ganoderma lucidum and Termitomyces titanicus significantly, in vitro, exhibited inhibition against mycelia spread of Trichophyton rubrum, Trichophton mentagrophytes, Microsporium spp in 4 weeks. The methanol and water crude extracts were formulated into petroleum base cream named Phytoderm^TM. Phytochemical analyses of extracts from Ganoderma and Termitomyces indicated flavonnoids, saponins, carbohydrates and cardiac Glycosides. The cream administered to 100 patients with 95% efficacy for all skin infections including herpes and Kaposi sarcoma.