临床药理学与生物药剂学

抽象的

Problems of using Hydrochlorothiazide Diuretic in Adult Diabeti c Patient in Diabetic Clinic of Adama Hospital Medical College, E ast Shoa Zone, Oromia Regional State, Ethiopia

Omer Aliyi, Mohammed Hussien and Belayneh Kefale

Background: Diabetes Mellitus (DM) is a group of common metabolic disorders that share the phenotype of hyperglycemia. Half century ago hydrochlorothiazide has been associated with a diagnosis of diabetes in hypertension treatment containing hydrochlorothiazide during long term therapy. This explained by association between glucose, potassium, and hydrochlorothiazide induced hyperglycemias and plasma insulin level. The objective of this study was to assess the problem associated with use of hydrochlorothiazide among adult diabetic patient in diabetic clinic of AHMC.

Methodology: A cross sectional study was carried out by reviewing patient information sheet and physician diagnosis card with a period from March, 25-May, 28, 2014. Data was collected from patient information sheet and physician diagnosis card by using check list and collected data was analyzing by using SPSS-20.

Result: In this study population the total of 1,200 patient cards with hypertension and type-2 diabetes were observed, from which only 60 patient have a problem associated with hydrochlorothiazide diuretic. Among these patient 55% were female and 38.3% were in the age group of 40-50 years and mean age was 51 years. Most of patient, 82% patient had increased FBS after HCT administration and around 90% of patient had decreased FBS after HCT discontinuation. Among the total number of the cases only in 5% showed high response to insulin and 37% low response to insulin. Most of the patient around 70% develop problem associated with HCT within start to six month.

Conclusion: In general in this study indicated that elevated fasting serum glucose level was the main problem associated with the use of HCT in adult diabetic patient