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Cellini F, Fiore M and Mattiucci G
In recent years the incidence of gastroesophageal junction (GEJ) tumors has been rapidly increasing. Many trials have investigated the role of preoperative radiochemotherapy for this specific subgroup. In past, GEJ tumors were sometimes considered either esophageal or gastric cancer, due to their anatomical location. Purpose of this paper is to elucidate the benefit of radiotherapy in combination with concurrent chemotherapy in neoadjuvant setting, reviewing the literature by the point of view of the recent classification provided for GEJ tumors.