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Real-Time Detection of Cardiomyocyte Phenomena under Hypoxia via Cell Analysis iCELLigence System
Chang-Hsun Ho and Chan-Yen Kuo
Ischemia/reperfusion (I/R) injury of cardiomyocytes is a leading cause of morbidity and mortality. Moreover, I/R injury induce overproduction of reactive oxygen species and causes cardiomyocyte death under hypoxia conditions. However, methods for monitoring cell conditions in real-time under hypoxia conditions are limited. In this study, we used a novel analysis tool, the iCELLigence System, to analyze the effect of hypoxia on H9c2 cells. The results showed that hypoxia caused cell growth inhibition or death via overproduction of reactive oxygen species.
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