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Resistance to Chemotherapy in Uterine Cancer: Mechanisms and Current therapies for Systemic treatment of Gynaecologic Malignancies

Routhu Gustavo

Uterine cancer, also known as endometrial cancer, is a type of cancer that originates in the lining of the uterus, called the endometrium. It is one of the most common gynecological cancers among women, primarily affecting those who have reached or are approaching menopause. Uterine cancer develops when the cells in the endometrium begin to grow uncontrollably, forming a tumor. This type of cancer can present various symptoms, such as abnormal vaginal bleeding (including post-menopausal bleeding), pelvic pain, and unusual vaginal discharge. While the exact cause of uterine cancer is not always clear, several risk factors, including hormonal imbalances, obesity, a family history of uterine or colon cancer, and certain medical conditions like polycystic ovary syndrome (PCOS), may increase the likelihood of its development.