姑息治疗与医学

抽象的

Salt Halo Therapy and Saline Inhalation Administered to Patients with Chronic Obstructive Pulmonary Disease: A Pilot Study

Ulla Møller Weinreich, Tove Nilsson, Lone Mylund, Helle Thaarup Christiansen and Birgitte Schantz Laursen

Introduction: Chronic Obstructive Pulmonary Disease (COPD) is characterised by progressive airflow limitation associated dyspnea and impaired quality of life. Halo therapy has been suggested to relieve respiratory discomfort in patients with COPD.
Aim: The aim of this study was to study the effect of halo therapy and isotonic saline inhalation, compared to controls, in COPD patients.

Material and methods: In this pilot cohort study 67 patients with COPD, GOLD stage 3 and 4, were included. Patients were assigned to 3 different groups; group 1 receiving 20 sessions of 45 minutes halo therapy with dry aerosols of salt less than 5 μm over 5 weeks, group 2 inhaling 5 ml isotonic Saline over 5 minutes, 5 weeks, 3 times per day and group 3 as controls. Spirometry, 6 minute walking test, dyspnea-score (MRC) and Quality-of-life (SGRQ) score was investigated at inclusion and at termination of the study.

Results: Group 1 improved walking distance 75 meters (p<0.01), SGRQ -6.66 points (p<0.05) and FEV1 0.4liters (2%), (p>0.05), during the treatment period. Group 2 improved FEV1 0.7 litres (3%) (p<0.05) and walkingdistance 90 metres (p<0.01). There was a drop out of 28% (7/25) in this group due to discomfort. Group 3 reduced MRC 1 point (p<0.05) and FEV1 0.6 litres (2%) (p = 0.051) during the observation period.

Conclusion: Both Halo therapy and saline inhalation improved walking distance and FEV1 in patients. SGRQ improved in patients treated with halo therapy. Halo therapy appeared to be better tolerated than saline therapy.