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K M Nazmul Islam Joy
Sporadic Inclusion Body myositis (s-IBM) represents a form of chronic polymyositis unresponsive to towards the corticosteroids, affecting patients over of 50 members. In contrast the hereditary Inclusion-Body Myopathy (h-IBM) strikes younger patients. Clinical hallmark of both forms are distal muscle involvement whereas the salient histopathological features were characterized by inflammatory exudates (only in s-IBM), rimmed vacuoles, eosinophilic cytoplasmic inclusions, 16 to 18 nm tubule filamentous inclusions in both cytoplasm and as well as in nucleus.