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Surfactant Metabolism Dysfunction Type 3 (SMDP3)

Yuns A Mohamed, Ahmed H Sharif, Muslim M AL Saadi, Mona M

Surfactant (surface-active-agent) is a compound of phospholipids and proteins which are synthesized and secreted into the alveolus by type II epithelial cells, where it functions to decrease surface tension, maintaining alveolar expansion, to facilitate pulmonary compliance.

Surfactant Proteins (SP) A, B, C, D represent around 8% of total components, but has vital role in optimizing rapid adsorption and spreading of phospholipids. ATP-binding cassette sub-family A member 3, protein that encoded by ABCA3 gene, which located in human chromosome 16p13.3, is synthesized in endoplasmic reticulum and migrated to lysosomal-derived organelles of alveolar type II cells, formally known as lamellar bodies. Once accumulate into the membrane, ABCA3 can direct surfactant phospholipid into the lumen of lamellar bodies and create tight packed of surfactant lipids and proteins. Mutation of the ATP-binding cassette transporter Gene ABCA3 cause failure in lamellar body synthesis and result in decreased production of surfactant, along with respiratory distress syndrome, and fatal respiratory failure.

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