疼痛与缓解杂志

抽象的

Systemic Review on the Use of Diclofenac/B Complex as an Anti-Inflammatory Treatment with Pain Relief Effect for Patients with Acute Lower Back Pain

Maribel Márquez*, Silvia Guzman and Herman Soto

Objective: the goal of this paper is to perform a systematic review on the use of diclofenac/B complex indicated for acute low back pain, compared to other available therapies for low back pain.
Material and Methods: The systematic review was performed on the following databases: Medline/Pubmed, Cochrane Library (CENTRAL), EMBASE, Imbiomed,LILACS, Artemisa and Nieto Editores, up until February 14th, 2015. A manual searchwas also performed on Google search. Key words were used under the MeSH terminology (Medical Subject Headings): low back pain, lumbago, diclofenac/vitamin B, non-steroidal anti-inflammatory, diclofenac, ibuprofen, naproxen, treatment. Study: Selection was performed by two investigators experts on the subject, selecting those studies with relevant information for the goal of this review.
Results: We found 261 studies with potential interest. Finally, 2 studies were selected, 1 clinical trial and a systematic review. The systematic review by Roelofs et al. (2011), which was done with Cochrane Collaboration and had as a goal to evaluate the effects of NDAIS´s and COX-2 inhibitors on non-specific low back pain treatment and to evaluate which NSAID´s was the most effective. The other selected study was a clinical trial performed by Mibielli et al. in 2009, a randomized study, double-blinded,with parallel groups, that included patients that received diclofenac and B complex andthe other arm received only diclofenac.
Conclusion: Diclofenac/B complex has a pain relief effect, anti-inflammatory and synergic neuro-regenerative effect, and this efficiency has been evaluated in several clinical studies where the administration of diclofenac plus vitamins B1, B6 and B12 decreases pain quicker, apart from being a safe drug.