Epidemiology: Open Access

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The Effect of Oral Supplementation of Vitamin D3 on Serum Levels of Vitamin D: A Review

Francesca Jarrett, Gloria Michelle Ducasa, David B Buller and Marianne Berwick

Due to the strong interest in the role of vitamin D in health, we tried to find data to illustrate the relationship between oral supplementation and change in serum levels of vitamin D. We reviewed the literature of randomized, placebo-controlled trials of oral supplementation and serum levels of vitamin D through 2014. We found 25 informative studies which showed a significant dose-response between oral supplementation and serum levels of vitamin D with an r2 of 0.61.These data are consistent with single studies and meta-analyses.In conclusion, the data show a consistent relationship that appears to be independent of multiple confounders.