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The Function Profiling of TIPE2 Reveals Links to its Potential Application
Guizhong Zhang and Suxia Liu
TIPE2, TNF-α-induced protein 8-like 2 (TNFAIP8L2), is a newly identified member of the TNFAIP8 family. Recent studies revealed that TIPE2 is a negative regulator of inflammation and carcinogenesis. TIPE2 deletion in mice causes fatal inflammation and its dysregulation in humans is associated with diseases, such as viral hepatitis, hepatocellular carcinoma, and atherosclerosis. The function profiling of TIPE2 in normal or pathological conditions indicates its potential application in immunotherapy.
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