国际标准期刊号: 2161-0681

临床与实验病理学杂志

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索引于
  • 哥白尼索引
  • 谷歌学术
  • 夏尔巴·罗密欧
  • 打开 J 门
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  • 哈姆达大学
  • 亚利桑那州EBSCO
  • OCLC-世界猫
  • 普布隆斯
  • 日内瓦医学教育与研究基金会
  • 欧洲酒吧
  • ICMJE
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The Prognostic Influence of CD44 in Oral Squamous Cell Carcinoma

Lucinei Roberto Oliveira, Andrielle Castilho-Fernandes and Alfredo Ribeiro-Silva

Oral Squamous Cell Carcinoma (OSCC) is the most frequent malignant tumor of the oral cavity, exhibiting a heterogeneous behavior. Because the mortality rate for this tumor has essentially remained unchanged over the last few decades, the need exists for more reliable prognostic factors in OSCC. The objective of this review was to examine the relevance of CD44 expression on the prognosis of OSCC patients through a critical analysis of the most significant current scientific literature on this subject. We found that most investigations of CD44 expression in OSCC over the years have demonstrated some prognostic influence, although there were significant differences among the studies. Certain studies have also demonstrated that CD44 may be an important biomarker of Cancer Stem Cells (CSCs) in OSCC. However, as with the discrepancies regarding the true prognostic value of CD44 in OSCC, some studies have indicated that CD44 might be limited in the identification of oral CSCs. Thus, according to our findings, additional and more standardized research should be conducted to validate the CD44 molecule as a reliable biomarker of prognosis and of CSCs in OSCC.