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Valéria Jósa, Valentin Brodszky, Zsombor Zrubka, Attila Zaránd, Tünde Mezei, Zsuzsanna Szilasi, Adrienne Fehér, Iván Igaz, Krisztián Somlai, Keresztély Merkel and Zsolt Baranyai
Introduction: IL-6 is an essential factor in inflammatory processes; its level has been found to be elevated in a variety of gastrointestinal tumors. Nearly 30% of IL-6 circulating in the blood is produced by adipose tissue; however, there are no clear data on whether its level changes in obese patients.
Material and method: We studied 127 patients with gastrointestinal tumors of different stages. IL-6 levels, white blood cell count (WBC), and hemoglobin (Hgb) concentration were determined in preoperative blood samples. BMI was determined with a calibrated calculator, before surgery. During the statistical analysis of the data, correlation was calculated using Spearman, Wilcoxon, and Pearson correlation coefficients.
Results: In patients with various gastrointestinal tumors, the level of circulating IL-6 was unrelated to BMI. This result was not influenced by hemoglobin concentration, or by white blood cell count.
Conclusion: In gastrointestinal tumors, IL-6 production by adipose tissue is negligible as compared with cytokine expression by the tumor and its environment.