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The role of Wnt signaling and treatment mechanism in leukemia
Seyyed Hossein Hassanpour, Mohammad Amin Dehghani, Seyyedeh Zeinab Karami, Fatemeh Dehghani
Increased activity of Wnt pathway has been observed in a huge number of malignancies. This pathway can function as a prosurvival factor in leukemia stem cells and early committed leukemic precursors and its inhibition is regarded as a therapeutic approach. Accordingly, the aim of this review is to evaluate the Wnt inhibitors used in leukemia models.
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