国际标准期刊号: 2381-8727

国际炎症、癌症和综合治疗杂志

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The role of Wnt signaling and treatment mechanism in leukemia

Seyyed Hossein Hassanpour, Mohammad Amin Dehghani, Seyyedeh Zeinab Karami, Fatemeh Dehghani

Increased activity of Wnt pathway has been observed in a huge number of malignancies. This pathway can function as a prosurvival factor in leukemia stem cells and early committed leukemic precursors and its inhibition is regarded as a therapeutic approach. Accordingly, the aim of this review is to evaluate the Wnt inhibitors used in leukemia models.