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Twin-Blade of a novel IMPDH Inhibitor FF-10501
Taichi Matsumoto
Since chemoresistance hampers a remission and results in a relapse of the patients with cancers, new approaches that do not rely on the existing strategies are needed. FF-10501 is a novel inhibitor for inosine monophosphate hydrogenase (IMPDH), a promising therapeutic target for cancer because IMPDH2 has been reported to be overexpressed in a variety of cancers. We previously reported the mechanism of cell death induced by FF-10501 using hematological malignant cell lines. FF-10501 induces not only apoptosis in a caspase-dependent manner but also induced non-apoptotic cell death. FF-10501 has the potential to be therapeutic drug for cancer and to overcome chemoresistance arise from apoptosis resistance.