牙科科学与医学杂志

抽象的

Under Mechanical Tension, Human Periodontal Ligament Stromal Cells Exhibit Differential Gene Expression and Protein-protein Interaction Networks

Benedict Sagl

Protein-protein interactions (PPIs) play a fundamental role in virtually all cellular processes, regulating signal transduction, enzymatic activities, gene expression, and protein function. Understanding the complex network of PPIs is crucial for deciphering cellular mechanisms and developing novel therapeutic strategies. This abstract provides an overview of protein-protein interactions, highlighting their importance, detection methods, and applications in various fields. PPIs are dynamic and intricate interactions that occur between two or more proteins through specific binding interfaces. These interactions can be transient or stable, and their disruption or alteration can lead to various diseases, including cancer, neurodegenerative disorders, and infectious diseases. Therefore, unraveling the mechanisms and functional consequences of PPIs has significant implications for drug discovery and precision medicine.