Epidemiology: Open Access

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Understanding the Genome-Wide Studies of the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium to Decipher the Genetic Architecture of Verbal Declarative Memory in Aging

Steven Debette

This study investigates the genetic determinants of verbal declarative memory in nondemented older individuals
through genome-wide studies within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Consortium. Leveraging diverse cohorts, the research employs genome-wide association studies to identify genetic
variants associated with verbal declarative memory. Preliminary findings highlight significant genetic loci linked to
cognitive function, providing insights into the molecular foundations of cognitive aging [1]. The study discusses the
collaborative nature of the CHARGE Consortium, emphasizing the potential for these genetic insights to inform
personalized interventions for cognitive health in aging populations.